Established in 2014, the College of Humanities and Sciences is among the most recent colleges in De La Salle Health Sciences Institute, along with the College of Pharmacy and the College of Medical Laboratory Science. It offers the three-year trimestral BS Biochemistry program with a two-year accelerated medicine track, the first accelerated medicine program with a strong chemistry preparation in the Philippines.
It was previously known as the General Education Department which housed various clusters in the fields of languages, literature, natural sciences, philosophy, religious education, social sciences, and physical education. In 2013, the various clusters were merged into two major integrated clusters – Integrated Humanities and Integrated Sciences and later turned into three departments namely: the Integrated Humanities, Integrated Sciences and the Chemistry and Biochemistry. In 2015, the three (3) departments have been restructured to only two (2) departments namely: Integrated Humanities and Sciences headed by a chair and the Chemistry headed by a Program Director. The College of Humanities and Sciences also serves as a servicing college to other undergraduate colleges in the institution for their GE courses.